Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000002835Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (897 aa)    
Predicted Functional Partners:
LOC113025693
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
  0.883
LOC113033094
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
  0.862
LOC113025455
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
  0.862
ENSACLP00000021542
Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.847
ENSACLP00000021867
Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
     
  0.847
MAPK8IP1
Mitogen-activated protein kinase 8 interacting protein 1.
    
 0.795
mapk8ip2
Mitogen-activated protein kinase 8 interacting protein 2.
    
 0.795
grb2
Growth factor receptor-bound protein 2b.
    
 
 0.724
LOC113017208
Mitogen-activated protein kinase kinase kinase.
    
 0.682
map3k10
Mitogen-activated protein kinase kinase kinase 10.
    
 0.682
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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