Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prkg2cGMP-dependent protein kinase. (773 aa)    
Predicted Functional Partners:
ENSACLP00000027327
Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
 0.909
gucy1b1
Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
 0.909
gucy1a1
Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
   
 0.907
GUCY1A2
Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
   
 0.907
LOC113009117
Regulator of G protein signaling 2.
    
 0.889
pln
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
   
 0.874
ENSACLP00000021285
Si:dkey-121j17.5; Belongs to the protein kinase superfamily.
     
  0.872
LOC113035556
cGMP-dependent protein kinase.
     
  0.871
ENSACLP00000025547
Uncharacterized protein; Belongs to the protein kinase superfamily.
     
  0.871
creb5
Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.
    
 0.868
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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