Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
GET1Guided entry of tail-anchored proteins factor 1. (170 aa)    
Predicted Functional Partners:
get3
ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]
    
 0.997
camlg
Calcium modulating ligand.
    
 0.994
ENSACLP00000031538
Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
    
 
 0.922
tgs1
LYN proto-oncogene, Src family tyrosine kinase.
    
   0.855
cog6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
    
   0.842
get4
Guided entry of tail-anchored proteins factor 4.
    
 0.829
ENSACLP00000010870
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
    
 0.828
tmem208
Transmembrane protein 208.
   
 
 0.812
sgta
Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha.
    
 0.796
ENSACLP00000039857
Small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta.
    
 0.796
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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