Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSACLP00000003716Calcium voltage-gated channel subunit alpha1 Ia. (2248 aa)    
Predicted Functional Partners:
ENSACLP00000029659
Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]
  
  
 
0.900
ENSACLP00000000350
Ion_trans domain-containing protein.
     
 
0.896
RASGRP2
RAS guanyl releasing protein 2.
     
  0.871
rasgrf2
Ras protein-specific guanine nucleotide-releasing factor 2b.
     
  0.871
ENSACLP00000018953
RAS guanyl releasing protein 3 (calcium and DAG-regulated).
     
  0.871
ENSACLP00000035057
Ras protein-specific guanine nucleotide-releasing factor 2a.
     
  0.871
ENSACLP00000013615
Calcium channel, voltage-dependent, T type, alpha 1H subunit a.
  
  
 
0.861
RASGRP1
RAS guanyl releasing protein 1.
     
  0.848
LOC113024911
Ras protein specific guanine nucleotide releasing factor 1.
     
  0.848
LOC113026808
Ras protein specific guanine nucleotide releasing factor 1.
     
  0.848
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.