Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cttnCortactin. (514 aa)    
Predicted Functional Partners:
LOC113013184
Tyrosine-protein kinase.
    
 0.969
SRC
Tyrosine-protein kinase.
    
 0.969
LOC113018933
Zgc:101810; Belongs to the actin family.
    
 0.967
actr2
Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.
    
 0.967
LOC113008847
Uncharacterized protein.
   
 0.951
LOC113026240
WASP like actin nucleation promoting factor a.
   
 0.951
LOC113007917
Actin related protein 3; Belongs to the actin family.
   
 0.943
LOC113016588
Uncharacterized protein; Belongs to the actin family.
   
 0.943
ENSACLP00000025627
Actin related protein 3B; Belongs to the actin family.
   
 0.943
LOC113025855
Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
    
 0.938
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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