Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000003814DEXH (Asp-Glu-X-His) box polypeptide 58. (677 aa)    
Predicted Functional Partners:
ifih1
Interferon induced with helicase C domain 1.
   
 0.990
mavs
CARD_2 domain-containing protein.
    
 0.988
top3a
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.934
ENSACLP00000020445
FA complementation group L.
    
 0.926
fancg
FA complementation group G.
    
 0.921
mus81
MUS81 structure-specific endonuclease subunit.
    
 0.920
fancf
FA complementation group F.
    
 0.917
ENSACLP00000008753
Uncharacterized protein.
    
 0.914
ENSACLP00000022421
FA complementation group C.
    
 0.914
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.912
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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