Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SMURF2E3 ubiquitin-protein ligase. (776 aa)    
Predicted Functional Partners:
smad7
Mothers against decapentaplegic homolog.
    
 0.978
RPS27A
Ribosomal protein S27a.
    
  0.973
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
 0.969
smad6
Mothers against decapentaplegic homolog.
    
 0.967
LOC113019522
Mothers against decapentaplegic homolog.
    
 0.967
ENSACLP00000009605
Ubiquitin B.
    
 0.954
LOC113030103
Uncharacterized protein.
    
 0.954
ccm2
CCM2 scaffold protein.
    
 0.949
TGFBR2
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.948
LOC113031657
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.948
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: low (14%) [HD]