Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
LOC113036345Beta-secretase 2; Belongs to the peptidase A1 family. (509 aa)    
Predicted Functional Partners:
LOC113007350
Amyloid beta (A4) precursor protein b.
    
 0.937
APP
Amyloid beta precursor protein.
    
 0.937
LOC113035437
Reticulon.
    
 0.838
ENSACLP00000006548
Reticulon.
    
 0.838
LOC113018043
Reticulon.
    
 0.838
LOC113035834
Reticulon.
    
 0.838
rtn1
Reticulon.
    
 0.838
aplp2
Amyloid beta (A4) precursor-like protein 2.
    
 0.837
LOC113024512
Uncharacterized protein.
    
 0.811
LOC113023714
Golgi associated, gamma adaptin ear containing, ARF binding protein 1.
    
 0.811
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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