Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pms1PMS1 homolog 1, mismatch repair system component. (897 aa)    
Predicted Functional Partners:
ENSACLP00000031218
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
0.999
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.998
ENSACLP00000003108
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.998
ENSACLP00000013446
Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.
    
 0.996
msh3
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.991
ENSACLP00000007406
Exonuclease 1.
   
 0.976
ENSACLP00000033842
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.968
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.957
RTEL1
Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]
   
 0.945
brip1
BRCA1 interacting protein C-terminal helicase 1.
   
 0.945
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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