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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC113008783SMYD family member 5. (417 aa)    
Predicted Functional Partners:
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.869
dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
    
 0.750
ENSACLP00000029365
Lysine (K)-specific methyltransferase 2E.
    
 0.747
prdm4
PR domain containing 4.
   
 0.692
ash2l
Ash2 like, histone lysine methyltransferase complex subunit.
    
 0.692
LOC113028169
Uncharacterized protein.
   
 0.692
psmd3
Proteasome 26S subunit, non-ATPase 3.
    
 0.689
rbbp5
Retinoblastoma binding protein 5.
    
 0.682
SETD2
SET domain containing 2, histone lysine methyltransferase.
     
 0.677
ENSACLP00000018302
Uncharacterized protein.
    
 0.676
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.