hacl1 protein (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hacl1

2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (568 aa)

Predicted Functional Partners:

zmynd19

0.913

LOC113030206

0.912

bcat1

0.879

LOC113020289

0.879

pex5

0.861

LOC113010236

0.848

pex5l

0.839

bckdha

0.819

cs

0.819

trip12

0.817

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113010236	LOC113030206	ENSACLP00000026121	ENSACLP00000009612	Peroxisomal biogenesis factor 5-like b.	Malate synthase-like.	0.872
LOC113010236	hacl1	ENSACLP00000026121	ENSACLP00000004601	Peroxisomal biogenesis factor 5-like b.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.848
LOC113010236	pex5	ENSACLP00000026121	ENSACLP00000036835	Peroxisomal biogenesis factor 5-like b.	Peroxisomal biogenesis factor 5.	0.871
LOC113020289	bckdha	ENSACLP00000033768	ENSACLP00000030951	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.943
LOC113020289	hacl1	ENSACLP00000033768	ENSACLP00000004601	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.879
LOC113020289	trip12	ENSACLP00000033768	ENSACLP00000009580	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Thyroid hormone receptor interactor 12.	0.539
LOC113030206	LOC113010236	ENSACLP00000009612	ENSACLP00000026121	Malate synthase-like.	Peroxisomal biogenesis factor 5-like b.	0.872
LOC113030206	bckdha	ENSACLP00000009612	ENSACLP00000030951	Malate synthase-like.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.836
LOC113030206	cs	ENSACLP00000009612	ENSACLP00000034208	Malate synthase-like.	Citrate synthase; Belongs to the citrate synthase family.	0.999
LOC113030206	hacl1	ENSACLP00000009612	ENSACLP00000004601	Malate synthase-like.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.912
LOC113030206	pex5	ENSACLP00000009612	ENSACLP00000036835	Malate synthase-like.	Peroxisomal biogenesis factor 5.	0.872
LOC113030206	pex5l	ENSACLP00000009612	ENSACLP00000029221	Malate synthase-like.	Peroxisomal biogenesis factor 5-like a.	0.872
bcat1	bckdha	ENSACLP00000011283	ENSACLP00000030951	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.943
bcat1	hacl1	ENSACLP00000011283	ENSACLP00000004601	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.879
bcat1	trip12	ENSACLP00000011283	ENSACLP00000009580	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Thyroid hormone receptor interactor 12.	0.539
bckdha	LOC113020289	ENSACLP00000030951	ENSACLP00000033768	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.943
bckdha	LOC113030206	ENSACLP00000030951	ENSACLP00000009612	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Malate synthase-like.	0.836
bckdha	bcat1	ENSACLP00000030951	ENSACLP00000011283	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.943
bckdha	cs	ENSACLP00000030951	ENSACLP00000034208	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Citrate synthase; Belongs to the citrate synthase family.	0.855
bckdha	hacl1	ENSACLP00000030951	ENSACLP00000004601	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.819