Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
LOC113008666FGFR1 oncogene partner 2. (224 aa)    
Predicted Functional Partners:
slmap
Sarcolemma associated protein a.
    
 
 0.926
LOC113007291-2
MOB family member 4, phocein.
    
 
 0.916
ikbke
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.909
tbk1
TANK-binding kinase 1.
    
 0.909
LOC113013057
Uncharacterized protein.
    
 
 0.876
ENSACLP00000004817
Striatin interacting protein 2.
    
 
 0.851
LOC113036096
Protein phosphatase 2, regulatory subunit A, beta b.
    
 
 0.851
strip1
Striatin interacting protein 1.
    
 
 0.851
LOC113013165
Sarcolemma associated protein b.
    
 
 0.849
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
    
 
 0.846
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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