Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Score
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1942 aa)    
Predicted Functional Partners:
LOC113032865
Sodium channel, voltage-gated, type I, beta a.
    
 0.969
scn4b
Sodium channel, voltage-gated, type IV, beta a.
    
 0.957
scn1b
Ig-like domain-containing protein.
    
 0.954
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.932
LOC113031102
Sodium channel, voltage-gated, type IV, beta b.
    
 0.922
LOC113032689
Si:ch211-225p5.8.
     
  0.902
scn2b
Sodium channel, voltage-gated, type II, beta.
   
 0.886
scn3b
Sodium channel, voltage-gated, type III, beta.
    
 0.844
gng10
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
 0.801
LOC113031178
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
 0.797
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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