STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
siva1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (164 aa)    
Predicted Functional Partners:
bcl2l1
BCL2 like 1.
    
 0.942
LOC113029594
BH4_2 domain-containing protein.
    
 0.869
bcl2
BCL2 apoptosis regulator b.
    
 0.869
bax
Uncharacterized protein.
    
 0.701
ENSACLP00000006475
Uncharacterized protein.
    
 0.701
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
   0.666
rad18
RAD18 E3 ubiquitin protein ligase.
    
 
 0.647
LOC113029596
Zgc:153993.
    
 0.628
ENSACLP00000006599
MCL1 apoptosis regulator, BCL2 family member b.
    
 0.628
LOC113021474
Uncharacterized protein.
    
 0.628
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: medium (80%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.