RTEL1 protein (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RTEL1

Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1123 aa)

Predicted Functional Partners:

ENSACLP00000013582

0.986

ENSACLP00000031218

0.985

ENSACLP00000007188

0.984

ENSACLP00000009352

0.977

LOC113008023

0.965

mre11

0.961

LOC113033395

0.959

ENSACLP00000017663

0.959

ercc3

0.959

pms2

0.956

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000007188	ENSACLP00000013582	ENSACLP00000007188	ENSACLP00000013582	DNA topoisomerase II binding protein 1.	Uncharacterized protein.	0.990
ENSACLP00000007188	LOC113008023	ENSACLP00000007188	ENSACLP00000027401	DNA topoisomerase II binding protein 1.	BRCA1 associated RING domain 1.	0.987
ENSACLP00000007188	RTEL1	ENSACLP00000007188	ENSACLP00000004731	DNA topoisomerase II binding protein 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.984
ENSACLP00000007188	mre11	ENSACLP00000007188	ENSACLP00000027130	DNA topoisomerase II binding protein 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.789
ENSACLP00000009352	ENSACLP00000013582	ENSACLP00000009352	ENSACLP00000013582	SMC5-SMC6 complex localization factor 1.	Uncharacterized protein.	0.960
ENSACLP00000009352	LOC113008023	ENSACLP00000009352	ENSACLP00000027401	SMC5-SMC6 complex localization factor 1.	BRCA1 associated RING domain 1.	0.999
ENSACLP00000009352	RTEL1	ENSACLP00000009352	ENSACLP00000004731	SMC5-SMC6 complex localization factor 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.977
ENSACLP00000009352	mre11	ENSACLP00000009352	ENSACLP00000027130	SMC5-SMC6 complex localization factor 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.994
ENSACLP00000013582	ENSACLP00000007188	ENSACLP00000013582	ENSACLP00000007188	Uncharacterized protein.	DNA topoisomerase II binding protein 1.	0.990
ENSACLP00000013582	ENSACLP00000009352	ENSACLP00000013582	ENSACLP00000009352	Uncharacterized protein.	SMC5-SMC6 complex localization factor 1.	0.960
ENSACLP00000013582	ENSACLP00000031218	ENSACLP00000013582	ENSACLP00000031218	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.921
ENSACLP00000013582	LOC113008023	ENSACLP00000013582	ENSACLP00000027401	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.999
ENSACLP00000013582	RTEL1	ENSACLP00000013582	ENSACLP00000004731	Uncharacterized protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.986
ENSACLP00000013582	mre11	ENSACLP00000013582	ENSACLP00000027130	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.991
ENSACLP00000013582	pms2	ENSACLP00000013582	ENSACLP00000022142	Uncharacterized protein.	PMS1 homolog 2, mismatch repair system component.	0.663
ENSACLP00000017663	LOC113033395	ENSACLP00000017663	ENSACLP00000008811	General transcription factor IIH, polypeptide 1.	General transcription factor IIH subunit.	0.999
ENSACLP00000017663	RTEL1	ENSACLP00000017663	ENSACLP00000004731	General transcription factor IIH, polypeptide 1.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.959
ENSACLP00000017663	ercc3	ENSACLP00000017663	ENSACLP00000033230	General transcription factor IIH, polypeptide 1.	Excision repair cross-complementation group 3.	0.999
ENSACLP00000031218	ENSACLP00000013582	ENSACLP00000031218	ENSACLP00000013582	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Uncharacterized protein.	0.921
ENSACLP00000031218	LOC113008023	ENSACLP00000031218	ENSACLP00000027401	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	BRCA1 associated RING domain 1.	0.773

page 1 of 4

Server load: medium (44%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About