Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1123 aa)    
Predicted Functional Partners:
ENSACLP00000013582
Uncharacterized protein.
   
 0.990
pms2
PMS1 homolog 2, mismatch repair system component.
   
 0.989
ENSACLP00000031218
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
   
 0.989
ENSACLP00000007188
DNA topoisomerase II binding protein 1.
   
 0.988
LOC113008023
BRCA1 associated RING domain 1.
  
 0.974
ENSACLP00000000444
Uncharacterized protein.
   
 0.963
nbn
Nibrin.
    
 0.954
palb2
PALB2_WD40 domain-containing protein.
   
 0.950
ENSACLP00000009352
SMC5-SMC6 complex localization factor 1.
  
 0.947
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.947
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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