STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)    
Predicted Functional Partners:
cdc6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.997
cdk2
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.988
ENSACLP00000006245
Protein kinase domain-containing protein.
   
 0.984
ENSACLP00000007272
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.984
ENSACLP00000009762
Chromatin licensing and DNA replication factor 1.
   
 0.980
ENSACLP00000035671
Cell division cycle 20 homolog.
   
 0.980
ENSACLP00000038411
Cell division cycle 20 homolog.
   
 0.980
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
   
 0.976
orc1
Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
   
 0.975
rb1
Retinoblastoma 1.
   
 0.969
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.