Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VAV1Vav guanine nucleotide exchange factor 1. (786 aa)    
Predicted Functional Partners:
LOC113022989
Cell division cycle 42.
   
 0.968
grb2
Growth factor receptor-bound protein 2b.
    
 0.935
ENSACLP00000016464
Tyrosine-protein kinase.
   
 0.929
syk
Tyrosine-protein kinase.
   
 0.929
LOC113034959
B cell linker.
    
 0.910
itk
Tyrosine-protein kinase.
   
 0.909
LOC113033441
Uncharacterized protein.
    
  0.890
LOC113010606
Phosphoinositide-3-kinase, regulatory subunit 3a (gamma).
    
  0.886
ENSACLP00000034020
Uncharacterized protein.
    
  0.886
LOC113010568
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
   
 
 0.852
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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