STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)    
Predicted Functional Partners:
CCND1
Cyclin D1; Belongs to the cyclin family.
   
 0.976
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.966
rb1
Retinoblastoma 1.
   
 0.960
LOC113022479
Cyclin D3; Belongs to the cyclin family.
   
 0.960
LOC113027151
Cyclin D2, a; Belongs to the cyclin family.
   
 0.957
LOC113009062
Cyclin D2, b; Belongs to the cyclin family.
   
 0.957
cdkn2d
Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4).
    
 0.956
CDKN2A
Cyclin dependent kinase inhibitor 2A.
    
 0.956
LOC113022485
Cyclin-dependent kinase inhibitor 1A.
   
 0.956
ccna1
Cyclin A1; Belongs to the cyclin family.
   
 0.955
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.