Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)    
Predicted Functional Partners:
CCND1
Cyclin D1; Belongs to the cyclin family.
   
 0.993
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.986
ccna1
Cyclin A1; Belongs to the cyclin family.
   
 0.985
ccnb1
Cyclin B1; Belongs to the cyclin family.
   
 0.985
CDKN2A
Cyclin dependent kinase inhibitor 2A.
    
 0.980
LOC113031225
Cyclin A2; Belongs to the cyclin family.
   
 0.977
ccnb3
Cyclin B3; Belongs to the cyclin family.
   
 0.975
LOC113022485
Cyclin-dependent kinase inhibitor 1A.
   
 0.975
ccne1
Cyclin E1; Belongs to the cyclin family.
   
 0.974
skp2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase.
   
 0.974
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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