Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC113007350Amyloid beta (A4) precursor protein b. (749 aa)    
Predicted Functional Partners:
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    
 0.982
sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.981
aplp2
Amyloid beta (A4) precursor-like protein 2.
   
  0.978
ENSACLP00000041064
Apolipoprotein Eb.
    
 0.975
LOC113025649
Uncharacterized protein; Belongs to the synuclein family.
    
 0.969
ENSACLP00000003345
Amyloid beta (A4) precursor protein-binding, family B, member 3.
    
 0.954
NCSTN
Nicastrin.
    
 0.954
hmmr
Hyaluronan-mediated motility receptor (RHAMM).
    
 0.941
ENSACLP00000003998
Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65).
    
 0.941
ENSACLP00000015052
PID domain-containing protein.
    
 0.941
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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