STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC113007350Amyloid beta (A4) precursor protein b. (749 aa)    
Predicted Functional Partners:
sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.957
nae1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    
 0.932
NCSTN
Nicastrin.
    
 0.931
ENSACLP00000014109
TNFR-Cys domain-containing protein.
    
 
 0.917
ENSACLP00000041064
Apolipoprotein Eb.
    
 0.895
pitrm1
Pitrilysin metallopeptidase 1.
    
 
 0.886
ENSACLP00000003345
Amyloid beta (A4) precursor protein-binding, family B, member 3.
    
 0.878
LOC113034568
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.866
LOC113034567
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.866
hmmr
Hyaluronan-mediated motility receptor (RHAMM).
    
 0.848
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.