Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)    
Predicted Functional Partners:
LOC113015699
Guanine nucleotide binding protein (G protein), alpha 11a (Gq class).
    
 0.928
LOC113011723
Guanine nucleotide binding protein (G protein), alpha 11b (Gq class).
    
 0.928
LOC113033130
Uncharacterized protein.
    
 0.928
GNA14
G protein subunit alpha 14.
    
 0.928
ENSACLP00000029412
Guanine nucleotide binding protein (G protein), alpha 14a.
    
 0.928
ENSACLP00000017448
Inositol 1,4,5-trisphosphate receptor, type 3.
    
 0.919
LOC113025585
Guanine nucleotide binding protein (G protein), alpha 14.
    
 0.916
ENSACLP00000020432
Guanine nucleotide binding protein (G protein), beta polypeptide 2.
    
 0.914
LOC113022298
Guanine nucleotide binding protein (G protein), beta polypeptide 1b.
    
 0.914
DGKQ
Diacylglycerol kinase.
     
 0.914
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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