Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pparaPeroxisome proliferator-activated receptor alpha a. (476 aa)    
Predicted Functional Partners:
ppargc1a
Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.
    
 0.977
sirt1
Deacetylase sirtuin-type domain-containing protein.
    
 0.950
med1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.913
ENSACLP00000018362
Serine/threonine-protein kinase TOR.
    
 0.879
PPARA
Peroxisome proliferator-activated receptor alpha b.
     
  0.872
PPARG
Peroxisome proliferator activated receptor gamma.
     
  0.866
ENSACLP00000010348
Nuclear receptor corepressor 1.
    
 0.865
ncor2
Nuclear receptor corepressor 2.
    
 0.865
rptor
Regulatory associated protein of MTOR, complex 1.
    
 0.839
ppard
Peroxisome proliferator-activated receptor delta b.
    
 0.838
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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