Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000005331Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)    
Predicted Functional Partners:
fzd4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.982
porcn
Porcupine O-acyltransferase like; Belongs to the membrane-bound acyltransferase family.
    
 0.960
fzd10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.958
ENSACLP00000010316
Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.957
fzd3
Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.957
FZD3
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.957
fzd6
Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.957
lrp6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.950
LOC113026267
Low density lipoprotein receptor-related protein 5.
    
 0.950
ENSACLP00000031693
Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.949
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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