hmgcll1 protein (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

hmgcll1

3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (341 aa)

Predicted Functional Partners:

oxct1

0.958

acaa1

0.939

LOC113030206

0.938

hadhb

0.937

LOC113025280

0.933

acat1

0.930

acat2

0.930

cs

0.926

acaa2

0.925

bcat1

0.921

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113025280	acaa1	ENSACLP00000028034	ENSACLP00000003773	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.987
LOC113025280	acaa2	ENSACLP00000028034	ENSACLP00000016258	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.988
LOC113025280	acat1	ENSACLP00000028034	ENSACLP00000000941	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.990
LOC113025280	acat2	ENSACLP00000028034	ENSACLP00000030899	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.990
LOC113025280	cs	ENSACLP00000028034	ENSACLP00000034208	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Citrate synthase; Belongs to the citrate synthase family.	0.926
LOC113025280	hadhb	ENSACLP00000028034	ENSACLP00000040374	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.993
LOC113025280	hmgcll1	ENSACLP00000028034	ENSACLP00000005334	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.933
LOC113025280	oxct1	ENSACLP00000028034	ENSACLP00000021754	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.933
LOC113030206	acaa1	ENSACLP00000009612	ENSACLP00000003773	Malate synthase-like.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.990
LOC113030206	acaa2	ENSACLP00000009612	ENSACLP00000016258	Malate synthase-like.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.952
LOC113030206	acat1	ENSACLP00000009612	ENSACLP00000000941	Malate synthase-like.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.952
LOC113030206	acat2	ENSACLP00000009612	ENSACLP00000030899	Malate synthase-like.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.952
LOC113030206	cs	ENSACLP00000009612	ENSACLP00000034208	Malate synthase-like.	Citrate synthase; Belongs to the citrate synthase family.	0.999
LOC113030206	hadhb	ENSACLP00000009612	ENSACLP00000040374	Malate synthase-like.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.952
LOC113030206	hmgcll1	ENSACLP00000009612	ENSACLP00000005334	Malate synthase-like.	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1.	0.938
acaa1	LOC113025280	ENSACLP00000003773	ENSACLP00000028034	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.987
acaa1	LOC113030206	ENSACLP00000003773	ENSACLP00000009612	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Malate synthase-like.	0.990
acaa1	acaa2	ENSACLP00000003773	ENSACLP00000016258	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.918
acaa1	acat1	ENSACLP00000003773	ENSACLP00000000941	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.890
acaa1	acat2	ENSACLP00000003773	ENSACLP00000030899	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family.	0.890