Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC113032033Uncharacterized protein. (182 aa)    
Predicted Functional Partners:
vti1b
Vesicle transport through interaction with t-SNAREs 1B.
    
   0.795
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
   0.763
LOC113034002
Vesicle-associated membrane protein 8 (endobrevin).
    
   0.752
stx8
Syntaxin 8.
    
   0.745
stx7
Syntaxin 7-like; Belongs to the syntaxin family.
    
   0.736
stx12
Syntaxin 12; Belongs to the syntaxin family.
    
   0.736
vti1a
Vesicle transport through interaction with t-SNAREs 1A.
    
   0.526
VAMP3
Vesicle associated membrane protein 3.
   
   0.522
smim24
Uncharacterized protein.
      
 0.521
ENSACLP00000002506
Uncharacterized protein.
    
 
 0.415
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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