Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000006123CULLIN_2 domain-containing protein; Belongs to the cullin family. (511 aa)    
Predicted Functional Partners:
rbx1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.981
ENSACLP00000006097
Uncharacterized protein.
 
     0.936
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 
 0.914
LOC113018914
NEDD8 ubiquitin like modifier.
    
 0.901
ENSACLP00000029713
Ubiquitin-like domain-containing protein.
    
 0.901
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
  0.723
ube2l3
Ubiquitin-conjugating enzyme E2L 3b; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.690
LOC113028579
Baculoviral IAP repeat containing 5a.
    
 0.689
ENSACLP00000031690
Leukocyte receptor cluster (LRC) member 8.
   
    0.674
ENSACLP00000005262
Uncharacterized protein.
   
    0.663
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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