Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ENSACLP00000006157Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (495 aa)    
Predicted Functional Partners:
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.724
rassf5
Ras association domain family member 5.
    
 0.553
ENSACLP00000022045
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
   0.537
ENSACLP00000015965
Protein kinase domain-containing protein.
  
 
   0.535
ENSACLP00000008544
Protein kinase domain-containing protein.
  
 
   0.532
sumo1
Small ubiquitin-related modifier.
    
 0.531
LOC113026884
Uncharacterized protein.
  
 
   0.526
ENSACLP00000037208
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
   0.522
LOC113024484
Peptidyl-prolyl cis-trans isomerase.
    
  0.509
ENSACLP00000015414
Uncharacterized protein.
   
 
 0.502
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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