Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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LOC113023329Retinol dehydrogenase 8b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)    
Predicted Functional Partners:
LOC113023319
LRAT domain-containing protein.
    
 0.896
ENSACLP00000020581
Hydroxysteroid (20-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.891
hsd17b12
Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 0.887
dhrs3
Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
  
 0.874
LOC113020812
Cytochrome P450, family 27, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.873
LOC113027757
Cytochrome P450, family 26, subfamily A, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.866
LOC113026744
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 
 0.853
ENSACLP00000030400
Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.853
sdr16c5
Short chain dehydrogenase/reductase family 16C, member 5a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
 0.841
LOC113019230
Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family.
   
 
 0.840
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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