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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (599 aa)    
Predicted Functional Partners:
ENSACLP00000035671
Cell division cycle 20 homolog.
   
 
  0.689
ENSACLP00000038411
Cell division cycle 20 homolog.
   
 
  0.689
PLK1
Serine/threonine-protein kinase PLK.
   
 
  0.642
plk2
Serine/threonine-protein kinase PLK.
   
 
  0.642
plk3
Serine/threonine-protein kinase PLK.
   
 
  0.642
ENSACLP00000032141
Polo-like kinase 4 (Drosophila).
   
 
 0.640
bub1b
BUB1 mitotic checkpoint serine/threonine kinase Bb.
   
 
  0.625
ect2
Epithelial cell transforming 2.
  
    0.624
espl1
Extra spindle pole bodies like 1, separase.
   
 
  0.597
FZR1
Fizzy/cell division cycle 20 related 1a.
   
 
  0.594
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.