LOC113030724 protein (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

LOC113030724

High mobility group box 1a. (206 aa)

Predicted Functional Partners:

becn1

0.951

LOC113018712

0.754

actr8

0.726

actr5

0.724

ino80c

0.717

ruvbl1

0.714

actl6a

0.707

polr1e

0.670

LOC113028491

0.665

supt16h

0.658

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC113018712	LOC113028491	ENSACLP00000007040	ENSACLP00000017385	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	H1 histone family, member 0.	0.605
LOC113018712	LOC113030724	ENSACLP00000007040	ENSACLP00000006405	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	High mobility group box 1a.	0.754
LOC113018712	actl6a	ENSACLP00000007040	ENSACLP00000028875	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Actin-like 6A; Belongs to the actin family.	0.626
LOC113018712	becn1	ENSACLP00000007040	ENSACLP00000013630	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Beclin 1, autophagy related.	0.902
LOC113018712	supt16h	ENSACLP00000007040	ENSACLP00000035186	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.706
LOC113028491	LOC113018712	ENSACLP00000017385	ENSACLP00000007040	H1 histone family, member 0.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.605
LOC113028491	LOC113030724	ENSACLP00000017385	ENSACLP00000006405	H1 histone family, member 0.	High mobility group box 1a.	0.665
LOC113028491	actl6a	ENSACLP00000017385	ENSACLP00000028875	H1 histone family, member 0.	Actin-like 6A; Belongs to the actin family.	0.801
LOC113028491	supt16h	ENSACLP00000017385	ENSACLP00000035186	H1 histone family, member 0.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.602
LOC113030724	LOC113018712	ENSACLP00000006405	ENSACLP00000007040	High mobility group box 1a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.754
LOC113030724	LOC113028491	ENSACLP00000006405	ENSACLP00000017385	High mobility group box 1a.	H1 histone family, member 0.	0.665
LOC113030724	actl6a	ENSACLP00000006405	ENSACLP00000028875	High mobility group box 1a.	Actin-like 6A; Belongs to the actin family.	0.707
LOC113030724	actr5	ENSACLP00000006405	ENSACLP00000031936	High mobility group box 1a.	Actin related protein 5; Belongs to the actin family.	0.724
LOC113030724	actr8	ENSACLP00000006405	ENSACLP00000029348	High mobility group box 1a.	Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.	0.726
LOC113030724	becn1	ENSACLP00000006405	ENSACLP00000013630	High mobility group box 1a.	Beclin 1, autophagy related.	0.951
LOC113030724	ino80c	ENSACLP00000006405	ENSACLP00000010592	High mobility group box 1a.	INO80 complex subunit C.	0.717
LOC113030724	polr1e	ENSACLP00000006405	ENSACLP00000020142	High mobility group box 1a.	RNA polymerase I subunit E.	0.670
LOC113030724	ruvbl1	ENSACLP00000006405	ENSACLP00000036347	High mobility group box 1a.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.714
LOC113030724	supt16h	ENSACLP00000006405	ENSACLP00000035186	High mobility group box 1a.	SPT16 homolog, facilitates chromatin remodeling subunit.	0.658
actl6a	LOC113018712	ENSACLP00000028875	ENSACLP00000007040	Actin-like 6A; Belongs to the actin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.626