| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSACLP00000006416 | RNF8 | ENSACLP00000006416 | ENSACLP00000035704 | Nudix (nucleoside diphosphate linked moiety X)-type motif 5; Belongs to the Nudix hydrolase family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.525 |
| ENSACLP00000006416 | cdc123 | ENSACLP00000006416 | ENSACLP00000006485 | Nudix (nucleoside diphosphate linked moiety X)-type motif 5; Belongs to the Nudix hydrolase family. | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | 0.674 |
| RNF8 | ENSACLP00000006416 | ENSACLP00000035704 | ENSACLP00000006416 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | Nudix (nucleoside diphosphate linked moiety X)-type motif 5; Belongs to the Nudix hydrolase family. | 0.525 |
| RNF8 | cdc123 | ENSACLP00000035704 | ENSACLP00000006485 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | 0.615 |
| c7h11orf58 | cdc123 | ENSACLP00000033439 | ENSACLP00000006485 | Zgc:56106. | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | 0.798 |
| cdc123 | ENSACLP00000006416 | ENSACLP00000006485 | ENSACLP00000006416 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Nudix (nucleoside diphosphate linked moiety X)-type motif 5; Belongs to the Nudix hydrolase family. | 0.674 |
| cdc123 | RNF8 | ENSACLP00000006485 | ENSACLP00000035704 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.615 |
| cdc123 | c7h11orf58 | ENSACLP00000006485 | ENSACLP00000033439 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Zgc:56106. | 0.798 |
| cdc123 | cops5 | ENSACLP00000006485 | ENSACLP00000038361 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | COP9 signalosome subunit 5. | 0.810 |
| cdc123 | eefsec | ENSACLP00000006485 | ENSACLP00000036270 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Eukaryotic elongation factor, selenocysteine-tRNA-specific. | 0.921 |
| cdc123 | eif2s1 | ENSACLP00000006485 | ENSACLP00000036230 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Eukaryotic translation initiation factor 2, subunit 1 alpha b. | 0.606 |
| cdc123 | eif2s2 | ENSACLP00000006485 | ENSACLP00000031404 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Eukaryotic translation initiation factor 2, subunit 2 beta. | 0.900 |
| cdc123 | eif2s3 | ENSACLP00000006485 | ENSACLP00000021948 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Eukaryotic translation initiation factor 2, subunit 3 gamma. | 0.964 |
| cdc123 | mrps17 | ENSACLP00000006485 | ENSACLP00000010500 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | Mitochondrial ribosomal protein S17. | 0.791 |
| cdc123 | wdfy2 | ENSACLP00000006485 | ENSACLP00000031046 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | WD repeat and FYVE domain containing 2. | 0.541 |
| cops5 | cdc123 | ENSACLP00000038361 | ENSACLP00000006485 | COP9 signalosome subunit 5. | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family. | 0.810 |
| cops5 | eefsec | ENSACLP00000038361 | ENSACLP00000036270 | COP9 signalosome subunit 5. | Eukaryotic elongation factor, selenocysteine-tRNA-specific. | 0.754 |
| cops5 | eif2s1 | ENSACLP00000038361 | ENSACLP00000036230 | COP9 signalosome subunit 5. | Eukaryotic translation initiation factor 2, subunit 1 alpha b. | 0.860 |
| cops5 | eif2s2 | ENSACLP00000038361 | ENSACLP00000031404 | COP9 signalosome subunit 5. | Eukaryotic translation initiation factor 2, subunit 2 beta. | 0.808 |
| cops5 | eif2s3 | ENSACLP00000038361 | ENSACLP00000021948 | COP9 signalosome subunit 5. | Eukaryotic translation initiation factor 2, subunit 3 gamma. | 0.754 |