Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ENSACLP00000006599MCL1 apoptosis regulator, BCL2 family member b. (278 aa)    
Predicted Functional Partners:
bax
Uncharacterized protein.
    
 0.989
ENSACLP00000006475
Uncharacterized protein.
    
 0.989
bcl2l1
BCL2 like 1.
    
 
 0.985
ENSACLP00000006726
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
 
 0.983
LOC113029596
Zgc:153993.
    
 
 0.980
becn1
Beclin 1, autophagy related.
    
 0.969
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.958
LOC113008499
Ubiquitin specific peptidase 9; Belongs to the peptidase C19 family.
    
 
 0.954
bmf
Uncharacterized protein.
    
 0.900
pink1
PTEN induced kinase 1.
    
 0.900
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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