Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000006681Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)    
Predicted Functional Partners:
hat1
Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.
    
 0.875
ENSACLP00000008692
AT rich interactive domain 4A (RBP1-like).
    
 0.864
ENSACLP00000034796
Translocase of outer mitochondrial membrane 20.
    
 0.864
RPS27A
Ribosomal protein S27a.
   
 0.796
MSL3
MSL complex subunit 3.
    
 0.795
mysm1
Myb-like, SWIRM and MPN domains 1.
    
  0.784
POLR2E
RNA polymerase II subunit E.
    
  0.778
sirt1
Deacetylase sirtuin-type domain-containing protein.
   
 0.774
uba52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
   
 0.774
polr2h
Info polymerase (RNA) II (DNA directed) polypeptide H.
    
  0.774
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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