Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSACLP00000007004NGFI-A binding protein 2 (EGR1 binding protein 2). (498 aa)    
Predicted Functional Partners:
egr2
Early growth response 2b.
   
 0.995
egr1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 0.835
nab1
NGFI-A binding protein 1a (EGR1 binding protein 1).
   
 0.835
egr3
Early growth response 3.
   
 0.826
ENSACLP00000004606
Chromodomain helicase DNA binding protein 5.
   
 0.794
ENSACLP00000013570
Chromodomain helicase DNA binding protein 3.
   
 0.794
ENSACLP00000023458
Chromodomain helicase DNA binding protein 4a.
   
 0.794
ENSACLP00000036203
Uncharacterized protein.
   
 0.794
aire
Autoimmune regulator.
   
 0.794
zc3h14
Zinc finger CCCH-type containing 14.
      
 0.669
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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