cop1 protein (Astatotilapia calliptera) - STRING interaction network

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Predicted Interactions

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Score

cop1

COP1 E3 ubiquitin ligase. (715 aa)

Predicted Functional Partners:

det1

0.987

ddb1

0.963

LOC113018712

0.941

ddb2

0.927

LOC113022113

0.881

cul4b

0.877

ENSACLP00000035328

0.877

rbx1

0.870

etv5

0.861

ercc8

0.860

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000035328	LOC113018712	ENSACLP00000035328	ENSACLP00000007040	Cullin 4A; Belongs to the cullin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.441
ENSACLP00000035328	cop1	ENSACLP00000035328	ENSACLP00000007039	Cullin 4A; Belongs to the cullin family.	COP1 E3 ubiquitin ligase.	0.877
ENSACLP00000035328	cul4b	ENSACLP00000035328	ENSACLP00000001998	Cullin 4A; Belongs to the cullin family.	Cullin 4B; Belongs to the cullin family.	0.863
ENSACLP00000035328	ddb1	ENSACLP00000035328	ENSACLP00000018313	Cullin 4A; Belongs to the cullin family.	Damage-specific DNA binding protein 1.	0.993
ENSACLP00000035328	ddb2	ENSACLP00000035328	ENSACLP00000020982	Cullin 4A; Belongs to the cullin family.	Damage-specific DNA binding protein 2.	0.967
ENSACLP00000035328	det1	ENSACLP00000035328	ENSACLP00000030950	Cullin 4A; Belongs to the cullin family.	DET1 partner of COP1 E3 ubiquitin ligase.	0.891
ENSACLP00000035328	ercc8	ENSACLP00000035328	ENSACLP00000023329	Cullin 4A; Belongs to the cullin family.	Excision repair cross-complementation group 8.	0.964
ENSACLP00000035328	rbx1	ENSACLP00000035328	ENSACLP00000020852	Cullin 4A; Belongs to the cullin family.	Ring-box 1, E3 ubiquitin protein ligase.	0.977
LOC113018712	ENSACLP00000035328	ENSACLP00000007040	ENSACLP00000035328	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cullin 4A; Belongs to the cullin family.	0.441
LOC113018712	LOC113022113	ENSACLP00000007040	ENSACLP00000005220	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Tribbles pseudokinase 3.	0.466
LOC113018712	cop1	ENSACLP00000007040	ENSACLP00000007039	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	COP1 E3 ubiquitin ligase.	0.941
LOC113018712	cul4b	ENSACLP00000007040	ENSACLP00000001998	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cullin 4B; Belongs to the cullin family.	0.441
LOC113018712	ddb1	ENSACLP00000007040	ENSACLP00000018313	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Damage-specific DNA binding protein 1.	0.428
LOC113018712	ddb2	ENSACLP00000007040	ENSACLP00000020982	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Damage-specific DNA binding protein 2.	0.926
LOC113018712	rbx1	ENSACLP00000007040	ENSACLP00000020852	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ring-box 1, E3 ubiquitin protein ligase.	0.467
LOC113022113	LOC113018712	ENSACLP00000005220	ENSACLP00000007040	Tribbles pseudokinase 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.466
LOC113022113	cop1	ENSACLP00000005220	ENSACLP00000007039	Tribbles pseudokinase 3.	COP1 E3 ubiquitin ligase.	0.881
LOC113022113	det1	ENSACLP00000005220	ENSACLP00000030950	Tribbles pseudokinase 3.	DET1 partner of COP1 E3 ubiquitin ligase.	0.501
cop1	ENSACLP00000035328	ENSACLP00000007039	ENSACLP00000035328	COP1 E3 ubiquitin ligase.	Cullin 4A; Belongs to the cullin family.	0.877
cop1	LOC113018712	ENSACLP00000007039	ENSACLP00000007040	COP1 E3 ubiquitin ligase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.941