LOC113018712 protein (Astatotilapia calliptera)

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LOC113018712

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (384 aa)

Predicted Functional Partners:

mdm4

0.999

chek2

0.999

mdm2

0.999

LOC113029596

0.998

rchy1

0.998

ENSACLP00000008384

0.998

UBE3A

0.998

usp7

0.998

sumo1

0.998

ENSACLP00000023092

0.998

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000008384	ENSACLP00000023092	ENSACLP00000008384	ENSACLP00000023092	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.491
ENSACLP00000008384	LOC113018712	ENSACLP00000008384	ENSACLP00000007040	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
ENSACLP00000008384	chek2	ENSACLP00000008384	ENSACLP00000013461	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Checkpoint kinase 2.	0.997
ENSACLP00000008384	mdm2	ENSACLP00000008384	ENSACLP00000018407	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	MDM2 proto-oncogene.	0.475
ENSACLP00000023092	ENSACLP00000008384	ENSACLP00000023092	ENSACLP00000008384	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.491
ENSACLP00000023092	LOC113018712	ENSACLP00000023092	ENSACLP00000007040	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998
ENSACLP00000023092	chek2	ENSACLP00000023092	ENSACLP00000013461	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Checkpoint kinase 2.	0.968
ENSACLP00000023092	mdm2	ENSACLP00000023092	ENSACLP00000018407	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	MDM2 proto-oncogene.	0.577
ENSACLP00000023092	sumo1	ENSACLP00000023092	ENSACLP00000018908	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Small ubiquitin-related modifier.	0.424
LOC113018712	ENSACLP00000008384	ENSACLP00000007040	ENSACLP00000008384	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
LOC113018712	ENSACLP00000023092	ENSACLP00000007040	ENSACLP00000023092	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.998
LOC113018712	LOC113029596	ENSACLP00000007040	ENSACLP00000000007	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Zgc:153993.	0.998
LOC113018712	UBE3A	ENSACLP00000007040	ENSACLP00000010931	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.998
LOC113018712	chek2	ENSACLP00000007040	ENSACLP00000013461	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Checkpoint kinase 2.	0.999
LOC113018712	mdm2	ENSACLP00000007040	ENSACLP00000018407	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM2 proto-oncogene.	0.999
LOC113018712	mdm4	ENSACLP00000007040	ENSACLP00000009363	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.999
LOC113018712	rchy1	ENSACLP00000007040	ENSACLP00000003341	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ring finger and CHY zinc finger domain containing 1.	0.998
LOC113018712	sumo1	ENSACLP00000007040	ENSACLP00000018908	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Small ubiquitin-related modifier.	0.998
LOC113018712	usp7	ENSACLP00000007040	ENSACLP00000015131	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family.	0.998
LOC113029596	LOC113018712	ENSACLP00000000007	ENSACLP00000007040	Zgc:153993.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.998

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