STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THAP1THAP domain containing 1. (237 aa)    
Predicted Functional Partners:
ENSACLP00000030247
Uncharacterized protein.
   
 0.790
ENSACLP00000031946
Uncharacterized protein.
   
 0.790
pln
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
  0.779
prkar2b
Protein kinase cAMP-dependent type II regulatory subunit beta.
   
 0.762
prkar1a
Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b.
   
 0.762
prkar2a
Protein kinase, cAMP-dependent, regulatory, type II, alpha A.
   
 0.762
ENSACLP00000031541
Protein kinase, cAMP-dependent, regulatory, type II, alpha, B.
   
 0.762
prkar1b
Protein kinase, cAMP-dependent, regulatory, type I, beta.
   
 0.762
bad
BCL2 associated agonist of cell death b.
    
 0.723
ENSACLP00000011345
Suppressor of fused homolog.
    
 0.711
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.