ddit4 protein (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ddit4

DNA-damage-inducible transcript 4. (225 aa)

Predicted Functional Partners:

ENSACLP00000030835

0.989

ENSACLP00000012749

0.904

tsc1

0.904

ENSACLP00000006726

0.887

LOC113009124

0.882

LOC113035061

0.872

LOC113018712

0.786

LOC113022176

0.781

LOC113031427

0.781

LOC113012094

0.781

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000006726	ENSACLP00000012749	ENSACLP00000006726	ENSACLP00000012749	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	Uncharacterized protein.	0.553
ENSACLP00000006726	LOC113018712	ENSACLP00000006726	ENSACLP00000007040	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.973
ENSACLP00000006726	ddit4	ENSACLP00000006726	ENSACLP00000007299	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	DNA-damage-inducible transcript 4.	0.887
ENSACLP00000006726	tsc1	ENSACLP00000006726	ENSACLP00000040094	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	TSC complex subunit 1b.	0.553
ENSACLP00000012749	ENSACLP00000006726	ENSACLP00000012749	ENSACLP00000006726	Uncharacterized protein.	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.	0.553
ENSACLP00000012749	ENSACLP00000030835	ENSACLP00000012749	ENSACLP00000030835	Uncharacterized protein.	TSC complex subunit 2.	0.998
ENSACLP00000012749	LOC113009124	ENSACLP00000012749	ENSACLP00000035100	Uncharacterized protein.	TBC1 domain family, member 7.	0.993
ENSACLP00000012749	LOC113012094	ENSACLP00000012749	ENSACLP00000028061	Uncharacterized protein.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family.	0.680
ENSACLP00000012749	LOC113018712	ENSACLP00000012749	ENSACLP00000007040	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.605
ENSACLP00000012749	LOC113022176	ENSACLP00000012749	ENSACLP00000010491	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.680
ENSACLP00000012749	LOC113031427	ENSACLP00000012749	ENSACLP00000013716	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.680
ENSACLP00000012749	LOC113035061	ENSACLP00000012749	ENSACLP00000019161	Uncharacterized protein.	Uncharacterized protein.	0.877
ENSACLP00000012749	ddit4	ENSACLP00000012749	ENSACLP00000007299	Uncharacterized protein.	DNA-damage-inducible transcript 4.	0.904
ENSACLP00000012749	tsc1	ENSACLP00000012749	ENSACLP00000040094	Uncharacterized protein.	TSC complex subunit 1b.	0.549
ENSACLP00000030835	ENSACLP00000012749	ENSACLP00000030835	ENSACLP00000012749	TSC complex subunit 2.	Uncharacterized protein.	0.998
ENSACLP00000030835	LOC113009124	ENSACLP00000030835	ENSACLP00000035100	TSC complex subunit 2.	TBC1 domain family, member 7.	0.999
ENSACLP00000030835	LOC113012094	ENSACLP00000030835	ENSACLP00000028061	TSC complex subunit 2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family.	0.902
ENSACLP00000030835	LOC113018712	ENSACLP00000030835	ENSACLP00000007040	TSC complex subunit 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.617
ENSACLP00000030835	LOC113022176	ENSACLP00000030835	ENSACLP00000010491	TSC complex subunit 2.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.902
ENSACLP00000030835	LOC113031427	ENSACLP00000030835	ENSACLP00000013716	TSC complex subunit 2.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.902