STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tlcd1TLC domain containing 1. (256 aa)    
Predicted Functional Partners:
dhrs7b
Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.799
pop4
POP4 homolog, ribonuclease P/MRP subunit.
      
 0.692
MED15
Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.638
MED15-2
Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.638
dhrs7c
Dehydrogenase/reductase (SDR family) member 7Ca.
    
 
 0.622
LOC113034610
Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.616
kdsr
3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.612
ENSACLP00000021789
RIMS binding protein 2.
      
 0.604
LOC113026250
Zgc:158868; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.600
ENSACLP00000000070
Carbonyl reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.562
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.