Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smyd4SET and MYND domain containing 4. (768 aa)    
Predicted Functional Partners:
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.795
prdm4
PR domain containing 4.
   
 0.785
mtmr14
Myotubularin related protein 14.
     
 0.762
dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
    
 0.759
ENSACLP00000029365
Lysine (K)-specific methyltransferase 2E.
    
 0.740
LOC113028169
Uncharacterized protein.
   
 0.739
SETD2
SET domain containing 2, histone lysine methyltransferase.
     
 0.728
LOC113022928
SET domain and mariner transposase fusion gene.
     
 0.723
rogdi
Rogdi atypical leucine zipper.
      
 0.722
cops7a
COP9 constitutive photomorphogenic homolog subunit 7A.
      
 0.719
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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