Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC113022665Dual specificity tyrosine phosphorylation regulated kinase 3. (604 aa)    
Predicted Functional Partners:
LOC113018712
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.829
ENSACLP00000018477
LisH domain-containing protein.
    
 
 0.798
DCAF1
DDB1 and CUL4 associated factor 1.
    
 
 0.798
ubr5
Ubiquitin protein ligase E3 component n-recognin 5.
    
 
 0.774
ddb1
Damage-specific DNA binding protein 1.
    
 
 0.772
mdm2
MDM2 proto-oncogene.
    
 0.724
ENSACLP00000004087
Uncharacterized protein.
    
 0.695
ENSACLP00000004131
TAN domain-containing protein.
    
 0.695
cep78
Centrosomal protein 78.
    
 
 0.674
RPS27A
Ribosomal protein S27a.
   
  0.669
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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