STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (525 aa)    
Predicted Functional Partners:
A0A484C571
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
  
 0.971
A0A484D3E7
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
  
 0.971
A0A484CME9
Uncharacterized protein.
   
 0.956
A0A484CCQ2
Ubiquitin-like domain-containing protein.
   
 0.951
A0A484D1R8
Ubiquitin-like domain-containing protein.
    
  0.945
A0A484DAL9
Uncharacterized protein.
    
 0.933
A0A484DQ49
Uncharacterized protein.
    
 0.923
A0A484CTX1
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.916
A0A484D4S0
UBIQUITIN_CONJUGAT_2 domain-containing protein.
   
 0.916
A0A484CUE7
Uncharacterized protein.
    
 0.910
Your Current Organism:
Perca flavescens
NCBI taxonomy Id: 8167
Other names: Morone flavescens, P. flavescens, yellow perch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.