| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A0A484C3V1 | A0A484CB92 | A0A484C3V1 | A0A484CB92 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.971 |
| A0A484C3V1 | A0A484CDZ9 | A0A484C3V1 | A0A484CDZ9 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.949 |
| A0A484C3V1 | A0A484CPG3 | A0A484C3V1 | A0A484CPG3 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.953 |
| A0A484C3V1 | A0A484CYJ6 | A0A484C3V1 | A0A484CYJ6 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.905 |
| A0A484C3V1 | A0A484D2I7 | A0A484C3V1 | A0A484D2I7 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.948 |
| A0A484C3V1 | A0A484D6U7 | A0A484C3V1 | A0A484D6U7 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.997 |
| A0A484C3V1 | A0A484DAZ4 | A0A484C3V1 | A0A484DAZ4 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.949 |
| A0A484C3V1 | A0A484DEN0 | A0A484C3V1 | A0A484DEN0 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.949 |
| A0A484C3V1 | A7XLV2_PERFV | A0A484C3V1 | A7XLV2 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Betaine homocysteine S-methyltansferase; Involved in the regulation of homocysteine metabolism. | 0.949 |
| A0A484C809 | A0A484CB92 | A0A484C809 | A0A484CB92 | S-adenosylmethionine decarboxylase proenzyme. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.955 |
| A0A484C809 | A0A484CPG3 | A0A484C809 | A0A484CPG3 | S-adenosylmethionine decarboxylase proenzyme. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.925 |
| A0A484C809 | A0A484CYJ6 | A0A484C809 | A0A484CYJ6 | S-adenosylmethionine decarboxylase proenzyme. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.449 |
| A0A484C809 | A0A484D2I7 | A0A484C809 | A0A484D2I7 | S-adenosylmethionine decarboxylase proenzyme. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.636 |
| A0A484C809 | A0A484D6U7 | A0A484C809 | A0A484D6U7 | S-adenosylmethionine decarboxylase proenzyme. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.461 |
| A0A484CB92 | A0A484C3V1 | A0A484CB92 | A0A484C3V1 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
| A0A484CB92 | A0A484C809 | A0A484CB92 | A0A484C809 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | S-adenosylmethionine decarboxylase proenzyme. | 0.955 |
| A0A484CB92 | A0A484CDZ9 | A0A484CB92 | A0A484CDZ9 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.876 |
| A0A484CB92 | A0A484CPG3 | A0A484CB92 | A0A484CPG3 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. | 0.954 |
| A0A484CB92 | A0A484CYJ6 | A0A484CB92 | A0A484CYJ6 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. | 0.968 |
| A0A484CB92 | A0A484D2I7 | A0A484CB92 | A0A484D2I7 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. | 0.963 |