Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
A0A484CD07Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (578 aa)    
Predicted Functional Partners:
A0A484D3G4
DHFR domain-containing protein.
    
 0.990
A0A484C8U6
Thymidylat_synt domain-containing protein.
     
 0.980
A0A484DDU6
Folate gamma-glutamyl hydrolase.
     
 0.949
A0A484DE77
Folate gamma-glutamyl hydrolase.
     
 0.949
A0A484C4Y9
Uncharacterized protein.
  
 
 0.891
A0A484C9K6
Uncharacterized protein.
  
 
 0.891
A0A484CI85
Uncharacterized protein.
  
 
 0.891
A0A484CL03
Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.
  
 0.873
A0A484CN87
SHMT domain-containing protein.
  
 0.873
A0A484D612
SHMT domain-containing protein.
  
 0.873
Your Current Organism:
Perca flavescens
NCBI taxonomy Id: 8167
Other names: Morone flavescens, P. flavescens, yellow perch
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