ENSSAUP00010051121 protein (Sparus aurata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSSAUP00010051121

annotation not available (280 aa)

Predicted Functional Partners:

ptprc

0.705

ptpn11

0.641

ptpn6

0.641

LOC115585499

0.641

tyrobp

0.604

LOC115594706

0.543

ENSSAUP00010027754

0.543

lgr4

0.518

rxfp1

0.518

LGR5

0.518

Your Current Organism:

Sparus aurata

NCBI taxonomy Id: 8175
Other names: Aurata aurata, S. aurata, Sparus auratus, gilthead bream, gilthead seabream, silver seabream

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSAUP00010027754	ENSSAUP00010051121	ENSSAUP00010027754	ENSSAUP00010051121	Oligodendrocyte myelin glycoprotein b.	annotation not available	0.543
ENSSAUP00010027754	ptprc	ENSSAUP00010027754	ENSSAUP00010058515	Oligodendrocyte myelin glycoprotein b.	Protein tyrosine phosphatase receptor type C.	0.412
ENSSAUP00010051121	ENSSAUP00010027754	ENSSAUP00010051121	ENSSAUP00010027754	annotation not available	Oligodendrocyte myelin glycoprotein b.	0.543
ENSSAUP00010051121	LGR5	ENSSAUP00010051121	ENSSAUP00010035010	annotation not available	Leucine rich repeat containing G protein-coupled receptor 5.	0.518
ENSSAUP00010051121	LOC115585499	ENSSAUP00010051121	ENSSAUP00010053950	annotation not available	Tyrosine-protein phosphatase non-receptor type 11-like.	0.641
ENSSAUP00010051121	LOC115594706	ENSSAUP00010051121	ENSSAUP00010026671	annotation not available	Oligodendrocyte-myelin glycoprotein-like.	0.543
ENSSAUP00010051121	lgr4	ENSSAUP00010051121	ENSSAUP00010004722	annotation not available	Leucine rich repeat containing G protein-coupled receptor 4.	0.518
ENSSAUP00010051121	ptpn11	ENSSAUP00010051121	ENSSAUP00010015261	annotation not available	Protein tyrosine phosphatase non-receptor type 11.	0.641
ENSSAUP00010051121	ptpn6	ENSSAUP00010051121	ENSSAUP00010039691	annotation not available	Protein tyrosine phosphatase non-receptor type 6.	0.641
ENSSAUP00010051121	ptprc	ENSSAUP00010051121	ENSSAUP00010058515	annotation not available	Protein tyrosine phosphatase receptor type C.	0.705
ENSSAUP00010051121	rxfp1	ENSSAUP00010051121	ENSSAUP00010025539	annotation not available	Relaxin family peptide receptor 1.	0.518
ENSSAUP00010051121	tyrobp	ENSSAUP00010051121	ENSSAUP00010005418	annotation not available	TYRO protein tyrosine kinase binding protein.	0.604
LGR5	ENSSAUP00010051121	ENSSAUP00010035010	ENSSAUP00010051121	Leucine rich repeat containing G protein-coupled receptor 5.	annotation not available	0.518
LGR5	lgr4	ENSSAUP00010035010	ENSSAUP00010004722	Leucine rich repeat containing G protein-coupled receptor 5.	Leucine rich repeat containing G protein-coupled receptor 4.	0.862
LGR5	ptprc	ENSSAUP00010035010	ENSSAUP00010058515	Leucine rich repeat containing G protein-coupled receptor 5.	Protein tyrosine phosphatase receptor type C.	0.415
LGR5	rxfp1	ENSSAUP00010035010	ENSSAUP00010025539	Leucine rich repeat containing G protein-coupled receptor 5.	Relaxin family peptide receptor 1.	0.567
LOC115585499	ENSSAUP00010051121	ENSSAUP00010053950	ENSSAUP00010051121	Tyrosine-protein phosphatase non-receptor type 11-like.	annotation not available	0.641
LOC115585499	ptprc	ENSSAUP00010053950	ENSSAUP00010058515	Tyrosine-protein phosphatase non-receptor type 11-like.	Protein tyrosine phosphatase receptor type C.	0.750
LOC115594706	ENSSAUP00010051121	ENSSAUP00010026671	ENSSAUP00010051121	Oligodendrocyte-myelin glycoprotein-like.	annotation not available	0.543
LOC115594706	ptprc	ENSSAUP00010026671	ENSSAUP00010058515	Oligodendrocyte-myelin glycoprotein-like.	Protein tyrosine phosphatase receptor type C.	0.412

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

74

PPI enrichment p-value:

0.289

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

7 of 52

1.72

2.94

1.41e-08

GO:0050896

Response to stimulus

11 of 363

1.07

1.41

2.67e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 57

1.68

2.78

2.82e-08

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 207

1.23

1.71

2.82e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 879

0.6

0.45

0.0036

GO:0016020

Membrane

10 of 1312

0.47

0.37

0.0036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3789

His Kinase A (phosphoacceptor) domain, and Histidine Phosphotransfer domain

10 of 19

2.31

7.95

3.57e-19

CL:3792

His Kinase A (phosphoacceptor) domain, and Histidine kinase-like ATPase domain

9 of 14

2.4

7.89

4.45e-18

CL:3770

His Kinase A (phosphoacceptor) domain, and cheY-homologous receiver domain

11 of 51

1.92

5.89

1.06e-18

CL:3796

His Kinase A (phosphoacceptor) domain

6 of 7

2.52

5.66

5.36e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 438

0.99

1.24

1.91e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

8 of 76

1.61

2.97

5.57e-10

KW-0418

Kinase

6 of 139

1.23

1.29

6.22e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 47

1.82

3.99

8.92e-12

SM00387

Histidine kinase-like ATPases

8 of 54

1.76

3.76

1.23e-11

SM00448

cheY-homologous receiver domain

8 of 57

1.74

3.68

1.23e-11

SM00073

Histidine Phosphotransfer domain

2 of 5

2.19

1.32

0.0032

SM00091

PAS domain

3 of 28

1.62

1.26

0.0018

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About