plod1 protein (Sparus aurata) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

plod1

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (774 aa)

Predicted Functional Partners:

LOC115589944

0.872

LOC115593219

0.872

LOC115592074

0.872

LOC115575105

0.872

ENSSAUP00010043599

0.871

suv39h1

0.831

SMYD3

0.823

LOC115593531

0.819

ENSSAUP00010003183

0.818

setd7

0.818

Your Current Organism:

Sparus aurata

NCBI taxonomy Id: 8175
Other names: Aurata aurata, S. aurata, Sparus auratus, gilthead bream, gilthead seabream, silver seabream

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSAUP00010003183	SMYD3	ENSSAUP00010003183	ENSSAUP00010018253	Nuclear receptor binding SET domain protein 3.	SET and MYND domain containing 3.	0.812
ENSSAUP00010003183	plod1	ENSSAUP00010003183	ENSSAUP00010052842	Nuclear receptor binding SET domain protein 3.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.	0.818
ENSSAUP00010003183	setd7	ENSSAUP00010003183	ENSSAUP00010022116	Nuclear receptor binding SET domain protein 3.	SET domain containing 7, histone lysine methyltransferase.	0.765
ENSSAUP00010003183	suv39h1	ENSSAUP00010003183	ENSSAUP00010003132	Nuclear receptor binding SET domain protein 3.	Suppressor of variegation 3-9 homolog 1.	0.734
ENSSAUP00010043599	plod1	ENSSAUP00010043599	ENSSAUP00010052842	Si:ch211-13f8.2.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.	0.871
LOC115575105	LOC115589944	ENSSAUP00010053454	ENSSAUP00010039817	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 1-like.	0.790
LOC115575105	LOC115592074	ENSSAUP00010053454	ENSSAUP00010046333	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 2-like.	0.833
LOC115575105	LOC115593219	ENSSAUP00010053454	ENSSAUP00010043840	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 2-like.	0.699
LOC115575105	plod1	ENSSAUP00010053454	ENSSAUP00010052842	Procollagen galactosyltransferase 1-like.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.	0.872
LOC115589944	LOC115575105	ENSSAUP00010039817	ENSSAUP00010053454	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 1-like.	0.790
LOC115589944	LOC115592074	ENSSAUP00010039817	ENSSAUP00010046333	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 2-like.	0.827
LOC115589944	LOC115593219	ENSSAUP00010039817	ENSSAUP00010043840	Procollagen galactosyltransferase 1-like.	Procollagen galactosyltransferase 2-like.	0.792
LOC115589944	plod1	ENSSAUP00010039817	ENSSAUP00010052842	Procollagen galactosyltransferase 1-like.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.	0.872
LOC115592074	LOC115575105	ENSSAUP00010046333	ENSSAUP00010053454	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 1-like.	0.833
LOC115592074	LOC115589944	ENSSAUP00010046333	ENSSAUP00010039817	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 1-like.	0.827
LOC115592074	LOC115593219	ENSSAUP00010046333	ENSSAUP00010043840	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 2-like.	0.791
LOC115592074	plod1	ENSSAUP00010046333	ENSSAUP00010052842	Procollagen galactosyltransferase 2-like.	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.	0.872
LOC115593219	LOC115575105	ENSSAUP00010043840	ENSSAUP00010053454	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 1-like.	0.699
LOC115593219	LOC115589944	ENSSAUP00010043840	ENSSAUP00010039817	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 1-like.	0.792
LOC115593219	LOC115592074	ENSSAUP00010043840	ENSSAUP00010046333	Procollagen galactosyltransferase 2-like.	Procollagen galactosyltransferase 2-like.	0.791

page 1 of 3

Network Stats

number of nodes:

9

number of edges:

8

average node degree:

1.78

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

0.602

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035385

Roundabout signaling pathway

3 of 4

3.15

2.96

4.27e-06

GO:0070100

Negative regulation of chemokine-mediated signaling pathway

3 of 6

2.97

2.81

7.51e-06

GO:0050919

Negative chemotaxis

4 of 37

2.31

2.75

4.36e-06

GO:0022028

Tangential migration from the subventricular zone to the olfactory bulb

3 of 8

2.85

2.68

1.23e-05

GO:0048846

Axon extension involved in axon guidance

3 of 10

2.75

2.6

1.60e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048495

Roundabout binding

3 of 7

2.9

2.39

4.30e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:19737524

(2009) The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.

4 of 18

2.62

2.09

0.00014

PMID:29907785

(2018) Inhibitory effect of SLIT2 on granulosa cell proliferation mediated by the CDC42-PAKs-ERK12 MAPK pathway in the prehierarchical follicles of the chicken ovary.

4 of 20

2.57

2.08

0.00014

PMID:32678266

(2020) Chemokine receptor CXCR7 non-cell-autonomously controls pontine neuronal migration and nucleus formation.

3 of 8

2.85

1.41

0.0028

PMID:27923383

(2016) srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.

3 of 9

2.8

1.41

0.0028

PMID:30906431

(2019) Antagonistic effects of exogenous Slit2 on VEGF-induced choroidal endothelial cell migration and tube formation.

3 of 11

2.71

1.4

0.0028

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17851

Regulation of commissural axon pathfinding by SLIT and ROBO, and Roundabout signaling pathway

8 of 11

3.13

10.23

6.74e-20

CL:17853

Roundabout signaling pathway, and Regulation of commissural axon pathfinding by SLIT and ROBO

4 of 6

3.1

4.47

6.69e-09

CL:20575

Cytoplasmic protein NCK, and p21 activated kinase binding domain

2 of 5

2.87

1.36

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ocu04360

Axon guidance

9 of 142

2.07

5.94

8.62e-16

ocu04012

ErbB signaling pathway

3 of 64

1.94

1.53

0.00088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-376176

Signaling by ROBO receptors

5 of 25

2.57

4.39

3.59e-09

MAP-9010553

Regulation of expression of SLITs and ROBOs

4 of 15

2.7

3.65

1.44e-07

MAP-422475

Axon guidance

7 of 385

1.53

2.3

1.50e-07

MAP-9675108

Nervous system development

7 of 402

1.51

2.26

1.51e-07

MAP-8985586

SLIT2:ROBO1 increases RHOA activity

2 of 3

3.1

1.83

0.00049

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0728

SH3 domain

4 of 173

1.64

1.43

0.00068

KW-0433

Leucine-rich repeat

3 of 104

1.73

1.15

0.0045

KW-0343

GTPase activation

2 of 48

1.89

0.83

0.0256

KW-0245

EGF-like domain

3 of 195

1.46

0.81

0.0186

KW-0677

Repeat

5 of 1117

0.92

0.58

0.0186

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR031160

F-BAR domain

3 of 18

2.49

1.62

0.0010

IPR013032

EGF-like, conserved site

3 of 20

2.45

1.62

0.0010

IPR006207

Cystine knot, C-terminal

3 of 19

2.47

1.62

0.0010

IPR035648

srGAP1/2/3, SH3 domain

2 of 2

3.27

1.48

0.0022

IPR000372

Leucine-rich repeat N-terminal domain

3 of 39

2.16

1.4

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00041

C-terminal cystine knot-like domain (CTCK)

3 of 17

2.52

2.15

0.00010

SM00282

Laminin G domain

3 of 37

2.18

1.75

0.00044

SM00274

Follistatin-N-terminal domain-like

2 of 7

2.73

1.57

0.0014

SM00326

Src homology 3 domains

4 of 174

1.63

1.49

0.00045

SM00082

Leucine rich repeat C-terminal domain

3 of 68

1.92

1.45

0.0013

(more ...)

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