LOC115590155 protein (Sparus aurata) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

LOC115590155

claudin-7-A. (233 aa)

Predicted Functional Partners:

LOC115592139

0.953

LOC115591696

0.945

ENSSAUP00010023678

0.937

ENSSAUP00010029944

0.937

LOC115592755

0.885

LOC115597161

0.874

esam

0.873

cldn11

0.868

cldn15

0.864

LOC115572140

0.864

Your Current Organism:

Sparus aurata

NCBI taxonomy Id: 8175
Other names: Aurata aurata, S. aurata, Sparus auratus, gilthead bream, gilthead seabream, silver seabream

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSAUP00010023678	ENSSAUP00010029944	ENSSAUP00010023678	ENSSAUP00010029944	Tight junction protein 1a.	Tight junction protein 1b.	0.846
ENSSAUP00010023678	LOC115572140	ENSSAUP00010023678	ENSSAUP00010043633	Tight junction protein 1a.	Claudin-1-like.	0.943
ENSSAUP00010023678	LOC115590155	ENSSAUP00010023678	ENSSAUP00010055329	Tight junction protein 1a.	claudin-7-A.	0.937
ENSSAUP00010023678	LOC115591696	ENSSAUP00010023678	ENSSAUP00010009295	Tight junction protein 1a.	Tight junction protein ZO-3-like.	0.593
ENSSAUP00010023678	LOC115592139	ENSSAUP00010023678	ENSSAUP00010003975	Tight junction protein 1a.	Occludin-like.	0.976
ENSSAUP00010023678	LOC115592755	ENSSAUP00010023678	ENSSAUP00010065922	Tight junction protein 1a.	Claudin-9-like.	0.875
ENSSAUP00010023678	LOC115597161	ENSSAUP00010023678	ENSSAUP00010038002	Tight junction protein 1a.	Claudin-4-like.	0.878
ENSSAUP00010023678	cldn11	ENSSAUP00010023678	ENSSAUP00010047728	Tight junction protein 1a.	Claudin 11.	0.896
ENSSAUP00010023678	cldn15	ENSSAUP00010023678	ENSSAUP00010013862	Tight junction protein 1a.	Claudin 15.	0.873
ENSSAUP00010029944	ENSSAUP00010023678	ENSSAUP00010029944	ENSSAUP00010023678	Tight junction protein 1b.	Tight junction protein 1a.	0.846
ENSSAUP00010029944	LOC115572140	ENSSAUP00010029944	ENSSAUP00010043633	Tight junction protein 1b.	Claudin-1-like.	0.942
ENSSAUP00010029944	LOC115590155	ENSSAUP00010029944	ENSSAUP00010055329	Tight junction protein 1b.	claudin-7-A.	0.937
ENSSAUP00010029944	LOC115591696	ENSSAUP00010029944	ENSSAUP00010009295	Tight junction protein 1b.	Tight junction protein ZO-3-like.	0.611
ENSSAUP00010029944	LOC115592139	ENSSAUP00010029944	ENSSAUP00010003975	Tight junction protein 1b.	Occludin-like.	0.976
ENSSAUP00010029944	LOC115592755	ENSSAUP00010029944	ENSSAUP00010065922	Tight junction protein 1b.	Claudin-9-like.	0.875
ENSSAUP00010029944	LOC115597161	ENSSAUP00010029944	ENSSAUP00010038002	Tight junction protein 1b.	Claudin-4-like.	0.848
ENSSAUP00010029944	cldn11	ENSSAUP00010029944	ENSSAUP00010047728	Tight junction protein 1b.	Claudin 11.	0.894
ENSSAUP00010029944	cldn15	ENSSAUP00010029944	ENSSAUP00010013862	Tight junction protein 1b.	Claudin 15.	0.873
LOC115572140	ENSSAUP00010023678	ENSSAUP00010043633	ENSSAUP00010023678	Claudin-1-like.	Tight junction protein 1a.	0.943
LOC115572140	ENSSAUP00010029944	ENSSAUP00010043633	ENSSAUP00010029944	Claudin-1-like.	Tight junction protein 1b.	0.942

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

59

PPI enrichment p-value:

0.138

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901607

Alpha-amino acid biosynthetic process

7 of 89

1.42

1.84

2.64e-06

GO:0044283

Small molecule biosynthetic process

8 of 257

1.02

1.05

2.34e-05

GO:0009099

Valine biosynthetic process

2 of 7

1.98

0.86

0.0236

GO:0009097

Isoleucine biosynthetic process

2 of 9

1.87

0.83

0.0260

GO:0019752

Carboxylic acid metabolic process

8 of 352

0.88

0.81

0.00014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004834

Tryptophan synthase activity

2 of 2

2.53

1.06

0.0116

GO:0019842

Vitamin binding

4 of 45

1.47

0.99

0.0061

GO:0030976

Thiamine pyrophosphate binding

2 of 5

2.13

0.82

0.0304

GO:0016829

Lyase activity

5 of 131

1.11

0.75

0.0087

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1200

0.49

0.4

0.00065

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:434

Branched-chain amino acid biosynthetic process

4 of 15

1.95

2.15

3.30e-05

CL:1011

Pyridoxal-phosphate dependent enzyme, and Gluconeogenesis

3 of 5

2.3

1.97

0.00018

CL:889

Biosynthesis of amino acids, and Transsulfuration

6 of 70

1.46

1.7

2.15e-05

CL:969

Sulfur amino acid metabolic process, and Pyridoxal-phosphate dependent enzyme

4 of 30

1.65

1.58

0.00026

CL:733

Cellular amino acid metabolic process, and Ribonucleoside monophosphate biosynthetic process

7 of 148

1.2

1.32

2.33e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00290

Valine, leucine and isoleucine biosynthesis

5 of 14

2.08

3.44

3.89e-08

map01230

Biosynthesis of amino acids

11 of 140

1.42

2.8

4.64e-14

map00260

Glycine, serine and threonine metabolism

6 of 58

1.54

2.26

2.90e-07

map00770

Pantothenate and CoA biosynthesis

4 of 20

1.83

2.23

1.11e-05

map00660

C5-Branched dibasic acid metabolism

3 of 11

1.96

1.9

0.00013

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005948

Acetolactate synthase complex

2 of 3

2.35

1.14

0.0080

GOCC:0005737

Cytoplasm

11 of 1077

0.54

0.45

0.00041

GOCC:0005829

Cytosol

7 of 555

0.63

0.4

0.0253

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0028

Amino-acid biosynthesis

6 of 66

1.48

1.9

4.40e-06

KW-0663

Pyridoxal phosphate

4 of 36

1.57

1.45

0.00043

KW-0822

Tryptophan biosynthesis

2 of 6

2.05

0.93

0.0174

KW-0100

Branched-chain amino acid biosynthesis

2 of 9

1.87

0.83

0.0256

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

3 of 7

2.16

1.51

0.0013

PF02776

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

2 of 3

2.35

0.9

0.0222

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

2 of 4

2.22

0.89

0.0222

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