LOC115584903 protein (Sparus aurata) - STRING interaction network

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Predicted Interactions

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LOC115584903

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2-like. (1618 aa)

Predicted Functional Partners:

LOC115581479

0.848

pip4k2a

0.848

pip5kl1

0.847

PIP4K2B

0.846

ipmk

0.846

ENSSAUP00010022226

0.846

ENSSAUP00010043358

0.843

ENSSAUP00010059887

0.841

INPP5A

0.839

ENSSAUP00010038200

0.823

Your Current Organism:

Sparus aurata

NCBI taxonomy Id: 8175
Other names: Aurata aurata, S. aurata, Sparus auratus, gilthead bream, gilthead seabream, silver seabream

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSAUP00010022226	ENSSAUP00010038200	ENSSAUP00010022226	ENSSAUP00010038200	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	0.861
ENSSAUP00010022226	ENSSAUP00010043358	ENSSAUP00010022226	ENSSAUP00010043358	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	0.845
ENSSAUP00010022226	ENSSAUP00010059887	ENSSAUP00010022226	ENSSAUP00010059887	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b.	0.846
ENSSAUP00010022226	LOC115581479	ENSSAUP00010022226	ENSSAUP00010004763	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like.	0.845
ENSSAUP00010022226	LOC115584903	ENSSAUP00010022226	ENSSAUP00010055827	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2-like.	0.846
ENSSAUP00010022226	PIP4K2B	ENSSAUP00010022226	ENSSAUP00010002833	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta.	0.848
ENSSAUP00010022226	pip4k2a	ENSSAUP00010022226	ENSSAUP00010036355	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.	0.806
ENSSAUP00010038200	ENSSAUP00010022226	ENSSAUP00010038200	ENSSAUP00010022226	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	0.861
ENSSAUP00010038200	ENSSAUP00010043358	ENSSAUP00010038200	ENSSAUP00010043358	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	0.852
ENSSAUP00010038200	ENSSAUP00010059887	ENSSAUP00010038200	ENSSAUP00010059887	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b.	0.861
ENSSAUP00010038200	LOC115581479	ENSSAUP00010038200	ENSSAUP00010004763	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like.	0.852
ENSSAUP00010038200	LOC115584903	ENSSAUP00010038200	ENSSAUP00010055827	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2-like.	0.823
ENSSAUP00010038200	PIP4K2B	ENSSAUP00010038200	ENSSAUP00010002833	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta.	0.896
ENSSAUP00010038200	pip4k2a	ENSSAUP00010038200	ENSSAUP00010036355	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.	0.861
ENSSAUP00010038200	pip5kl1	ENSSAUP00010038200	ENSSAUP00010060231	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	Phosphatidylinositol-4-phosphate 5-kinase like 1.	0.852
ENSSAUP00010043358	ENSSAUP00010022226	ENSSAUP00010043358	ENSSAUP00010022226	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a.	0.845
ENSSAUP00010043358	ENSSAUP00010038200	ENSSAUP00010043358	ENSSAUP00010038200	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma.	0.852
ENSSAUP00010043358	ENSSAUP00010059887	ENSSAUP00010043358	ENSSAUP00010059887	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b.	0.845
ENSSAUP00010043358	LOC115581479	ENSSAUP00010043358	ENSSAUP00010004763	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like.	0.847
ENSSAUP00010043358	LOC115584903	ENSSAUP00010043358	ENSSAUP00010055827	Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2-like.	0.843

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.794

expected number of edges:

16

PPI enrichment p-value:

0.00371

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051537

2 iron, 2 sulfur cluster binding

5 of 22

1.81

2.24

9.19e-06

GO:0016491

Oxidoreductase activity

8 of 384

0.78

0.62

0.0015

GO:0043167

Ion binding

9 of 811

0.5

0.35

0.0186

GO:0005488

Binding

11 of 1306

0.38

0.3

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2121

Mixed, incl. AMP-binding enzyme C-terminal domain, and 2Fe-2S

7 of 28

1.86

3.45

2.49e-09

CL:2124

Mixed, incl. Cytochrome P450, and Phosphopantetheine

5 of 11

2.11

3.14

2.72e-07

CL:2126

Phosphopantetheine, and Oxidoreductase NAD-binding domain

4 of 5

2.36

3.03

1.31e-06

CL:1521

Glutamate synthase activity, and Gas transport

2 of 6

1.98

0.8

0.0314

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00360

Phenylalanine metabolism

3 of 29

1.47

0.81

0.0192

map01120

Microbial metabolism in diverse environments

6 of 342

0.7

0.42

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0001

2Fe-2S

5 of 10

2.16

3.36

1.06e-07

KW-0408

Iron

6 of 61

1.45

1.87

3.13e-06

KW-0596

Phosphopantetheine

2 of 3

2.28

1.26

0.0045

KW-0479

Metal-binding

6 of 219

0.9

0.71

0.0021

KW-0349

Heme

2 of 13

1.64

0.71

0.0385

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00111

2Fe-2S iron-sulfur cluster binding domain

5 of 10

2.16

3.19

2.62e-07

PF00970

Oxidoreductase FAD-binding domain

4 of 4

2.46

3.06

1.39e-06

PF00175

Oxidoreductase NAD-binding domain

4 of 4

2.46

3.06

1.39e-06

PF00550

Phosphopantetheine attachment site

2 of 3

2.28

1.01

0.0138

PF00067

Cytochrome P450

2 of 3

2.28

1.01

0.0138

(more ...)

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