STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)    
Predicted Functional Partners:
pln
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.976
prkar1b
Uncharacterized protein.
 
 
 0.974
LOC108897934
Uncharacterized protein.
 
 
 0.973
prkar1a
Uncharacterized protein.
 
 
 0.973
LOC108888492
Uncharacterized protein.
 
 
 0.973
LOC108882544
Uncharacterized protein.
 
 
 0.973
smo
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.948
Itpr2
Inositol 1,4,5-trisphosphate receptor, type 2.
    
 0.942
ENSLCAP00010049689
Inositol 1,4,5-trisphosphate receptor, type 1a.
    
 0.942
Gli3
Uncharacterized protein.
    
 0.940
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.