STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
smyd3Uncharacterized protein. (445 aa)    
Predicted Functional Partners:
LOC108879980
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.874
ENSLCAP00010041482
Mitogen-activated protein kinase kinase kinase 2.
   
 
 0.782
ENSLCAP00010027353
Uncharacterized protein.
     
 0.700
Ash2l
Ash2 like, histone lysine methyltransferase complex subunit.
    
 0.696
plod2
Fe2OG dioxygenase domain-containing protein.
   
 0.683
LOC108892696
Fe2OG dioxygenase domain-containing protein.
   
 0.683
ENSLCAP00010012626
Mitogen-activated protein kinase kinase kinase 3.
   
 
 0.676
LOC108881705
Protein kinase domain-containing protein.
   
 
 0.676
ENSLCAP00010054111
Helicase with zinc finger.
    
 0.669
rbbp5
WD_REPEATS_REGION domain-containing protein.
    
 0.667
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.