STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (214 aa)    
Predicted Functional Partners:
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.968
KXG89425.1
ImpB/MucB/SamB family protein; KEGG: cgo:Corgl_0698 6.5e-102 DNA-directed DNA polymerase K03502; Psort location: Cytoplasmic, score: 7.50.
 
 
 0.911
KXG91356.1
Hypothetical protein; Psort location: CytoplasmicMembrane, score: 10.00.
       0.786
KXG90268.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.745
KXG88502.1
DnaQ family exonuclease/DinG family helicase; KEGG: ols:Olsu_0005 2.3e-177 DNA polymerase III subunit epsilon K03722; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.689
KXG91404.1
CRISPR-associated endoribonuclease Cas2; KEGG: brm:Bmur_2247 5.3e-20 DNA polymerase III subunit epsilon; K02342 DNA polymerase III subunit epsilon; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.635
KXG88889.1
Putative ATP-dependent DNA helicase PcrA; KEGG: ols:Olsu_1470 1.8e-273 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97.
     
 0.617
KXG91086.1
KEGG: ols:Olsu_0735 7.8e-232 exonuclease RecJ K07462; Psort location: Cytoplasmic, score: 7.50.
     
 0.606
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.562
ruvA
Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
  
 0.554
Your Current Organism:
Atopobium vaginae
NCBI taxonomy Id: 82135
Other names: A. vaginae, ATCC BAA-55, ATCC:BAA 55, ATCC:BAA:55, CCUG 38953, CIP 106431, DSM 15829, NCTC 13935
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